INTERMEDIARY METABOLISM

What?? Fate of dietary components after digestion and absorption. Flow of molecules through metabolic pathways and interaction between these pathways.

Liver: Primary metabolic organ - functions to regulate blood concentration of most metabolites (glucose, amino acids, etc.)

Hepatic Portal Vein: vein that caries absorbed nutrients from G.I. tract to liver

Cells: the level at which metabolic pathways occur.

*glycolysis

gluconeogenesis

lipolysis

*Krebs (TCA, citric acid) cycle

b -oxidation

*Electron transport

anaerobic = O2 not present (cytoplasm)

aerobic = O2 present (mitochondria)

 

GLYCOLYSIS

Net Reaction:

Glucose + 2 ADP + 2 Pi ® 2 pyruvate + 2 ATP + 2 NADH

Anaerobic= No O2 required, cytoplasm

 

KREBS (TCA, CITRIC ACID) CYCLE

Net Reaction:

2 pyruvate ® 2 AcetylCo-A + 2 CO2 + 2 NADH

2 AcetylCo-A ® 4 CO2 + 6 NADH + 2 FADH2 + 2 GTP

Aerobic= Requires O2, mitochondria

Assume tha 1 GTP = 1 ATP Þ have 4 ATP net thus far.